Dr. Parinita Agrawal
PhD Senior Research Scientist,
Lead – Biomaterials platform
Organ regeneration and model development has been a dream across the world. To find a solution to this challenge, Pandorum Technologies Pvt Ltd succeeds to create 3D Bioprinted models. Pandorum uses its proprietary technology platform to develop advanced therapeutic formulations consisting of cell modulators and biopolymers for the regenerative treatment of human tissues, including the Cornea, Lung, and Liver.
Pandorum’s vision is to make ‘Tissue Engineering’ a scalable reality. With the company’s flagship project ‘Liquid Cornea’ intended to treat epithelial and stromal corneal wounds, heading for clinical trials in early 2023, the company is set to be a game changer in the regenerative medicine domain in India and globally.
Implanting printed corneas – entering human trials in India and USA
Globally, millions of people suffer from unilateral and bilateral corneal blindness. Pandorum Technologies has 3D Bioprinted a Lenticule (by making use of one of two bioprinting methods which were micro-extrusion-based 3D bioprinting using the BioX and DLP which is light-based 3D bioprinting using the LumenX+) for corneal implantation. Their emphasis has been on recreating the corneal tissue equivalent, that is conducive for corneal tissue engineering and regenerative medicine, thereby mimicking the physiology and functionality of the corneal epithelium, corneal stroma, and endothelium.
A cornea lenticule that is 3D bioprinted in the lab as an alternative to donor cornea, ready to be used in the place of donor cadaveric cornea in patients with cornea damage.
“Both the 3D bioprinters (BioX and LumenX+) have a user-friendly interface. Flexible in operation and versatile, it was easy to adapt the technology as per the requirements of our bio-ink formulations. We have utilized these properties to get a wider range of printed structures to create robust models and printers along with the vast array of resources and customer care support. And not to mention, the affordable price was also one of the factors that played an important role for a start-up like us.”
Dr. Parinita Agrawal,
PhD Senior Research Scientist,
Lead – Biomaterials platform
Mini-liver tissue with channels
Mini liver tissue to mimic liver lobules (hexagonal repeating units), having complex vascular network, bioprinted using bioink developed in Pandorum.
Compatibility of the bioink shown with micro scale liver organoids comprising of multi cell component which mimics the makeup of native liver.
Publication Date : November, 2022
